Chitosan based co-processed excipient for improved tableting

Development of Directly Compressible Co-processed Excipient for Dispersible Tablets Using 3 Full Factorial Design

The purpose of the present research was to prepare and evaluate mannitol and cellulose based, directly compressible excipient using freeze-thawing technique. The mannitol to cellulose ratio (50:50, 60:40, and 70:30) and the rotation speed of propeller stirrer (200, 600, and 1000 rpm) were selected as independent variables in a 3 full factorial design. Water acted as a good medium for mannitol a...

Co-Processed Chitin-Mannitol as a New Excipient for Oro-Dispersible Tablets

This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll compaction (RC). Differential scanning calorimetry (DSC), Fourier transform-In...

Potential aspects of chitosan as pharmaceutical excipient.

Interest in use of the polysaccharide chitosan as a pharmaceutical excipient by different dose routes and for a number of applications is not new but it still does not appear to be present in any marketed drugs. Also a novel excipient in a new formulation requires a lot of safety consideration. Published literature showed that chitosan has low oral toxicity and prior human exposure has occurred...

Assessing the performance of a co-processed HPMC-lactose excipient using an instrumented tablet press

Design and Characterization of Oral Dispersible Tablets of Enalapril Maleate Using a Co-Processed Excipient

Article history: Received on: 20/10/2012 Revised on: 06/11/2012 Accepted on: 15/11/2012 Available online: 28/11/2012 In the present work, oral dispersible tablets of Enalapril maleate were prepared using three different superdisintegrants and a co-processed superdisintegrant consisting of crospovidone and sodium starch glycolate in the ratio 1:1. Oral dispersible tablets of Enalapril maleate we...